It is a recurrent clinical phenomenon requiring swift identification to minimize deleterious effects. The distinction one could make is that fluid in the interstitium is still readily available to either the intravascular or the intracellular compartments, in response to ionic changes, whereas that which is pooled in the bowel (third space) is not so readily available. The interstitial space could be considered to be a sub-section of the extracellular compartment. Third space is also a term used to refer to, for example, the bowel with an ileus, and the collection of fluid therein, usually post-operatively. An example of severe third spacing is ascites, as seen in severe liver failure as a result of a low albumin level in the circulating blood. Extensive tissue swelling occurs when the third space fills with excess fluid, known as edema. The third space where bodily fluid resides is the interstitial space, or the space filled with interstitial fluid between the cells within the tissues. Third-space fluid shift is the mobilization of body fluid to a non-contributory space rendering it unavailable to the circulatory system.
Third spacing is the physiological concept that body fluids may collect in a "third" body compartment that isn't normally perfused with fluids. plasma) in an approximately 75%-25% ratio. tissue) and intravascular compartment (i.e. In human physiology, extracellular fluids are distributed between the interstitial compartment (i.e. Associate Editor-In-Chief: M.Umer Tariq Overview List of terms related to Third spacing of fluidsĮditor-In-Chief: C. Third spacing of fluids in the Marketplace Risk calculators and risk factors for Third spacing of fluidsĬauses & Risk Factors for Third spacing of fluidsĭiagnostic studies for Third spacing of fluids Patient Handouts on Third spacing of fluidsĭirections to Hospitals Treating Third spacing of fluids Patient resources on Third spacing of fluidsĭiscussion groups on Third spacing of fluids US National Guidelines Clearinghouse on Third spacing of fluidsīe alerted to news on Third spacing of fluids
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